"Bloody" Mary, a vampire with a death wish, has spent the past 400 years chasing down a modern-day exorcist named Maria who is thought to have inherited "The Blood of Maria" and is the only one who can kill Mary. To Mary's dismay, Maria doesn't know how to kill vampires. Desperate to die, Mary agrees to become Maria's bodyguard until Maria can find a way to kill him.

No one knew that the death and resurrection of "Mary" was actually an attempt to revive the weak and ailing Mary. When Mary learns this truth, he hears the voice of "Mary." And now Maria must finally fulfill Mary's death wish... But still a greater tragedy awaits...