Champagne, France, 1800. Twenty-year-old Barbe-Nicole inherited Le Nez (an uncanny sense of smell) from her great-grandfather, a renowned champagne maker. Determined to use Le Nez to make great champagne, she learns her childhood sweetheart, François Clicquot, wants to start a winery and marries him despite his mental illness.

Her husband's tragic death forces her to become Veuve (Widow) Clicquot and grapple with a domineering partner, the complexities of making champagne, and six Napoleon wars, which cripple her ability to sell champagne. When she falls in love with her sales manager, Louis Bohne, who asks her to marry, she must choose between losing her winery to her husband, as dictated by Napoleon Code, or losing Louis.

In the ultimate showdown, Veuve Clicquot risks imprisonment and even death, defying Napoleon himself.