Eve Dallas must stray into the bowels of New York City when she is called to a street sleeper's homicide. All expectations go out the window when she discovers a laser-perfect hole where his heart used to be - the work of a highly skilled surgeon.

Research reveals that similar deaths have been occurring across America and Europe, but all her efforts to work out why are confused by the fact that the organs are always faulty. As she digs further and the medical community shuts against her, Eve's problems become much worse as an internal investigation leaves her suspended from action and fighting to retain her fragile sense of identity. Eve and those loyal to her must go to even greater lengths as they get closer to the mastermind killer and the stakes are raised.