Paul Brickner and his twelve-year-old daughter Spring are subletting an apartment in New York City. They came to escape the sorrow of their empty house in upstate New York after Nadia, Paul's wife and Spring's mother, dies.

Spring quickly takes to her new Manhattan middle school life, including making a new friend, Irina. Through that connection, Paul meets Irina's mother, Tara White, a blues singer, and perhaps just the spark Paul has been missing.

But Paul begins to fear that he is being haunted by Nadia, who appears to him in fleeting images. Is he imagining it, or is she real? Tara, who grew up in the inscrutable New England cult known as the Dream People, is haunted, too, hounded by her very real brothers to return to the family, and to give back the magical object-a shamanic Tibetan vessel-that they claim she stole from them.

Paul's cousin Hank, a disreputable art dealer, becomes obsessed with this object. Meanwhile, Paul's father-in-law, an expert on occult lore, tries to steer Paul toward resolution with Nadia's ghost.

Driven by Paul's new circle of odd and free spirited iconoclasts, Dangerous Blues asks the question: when do you let go, and what are you willing to let go of?