Information system (IS) researchers play a pivotal role as change agents, driving positive societal transformation and addressing "grand challenges." Designing for Digital Transformation in a Society of Smartness explores and expands the literature on digital transformation (DT), focusing on how IS research can conceptualize and tackle the design of IS artifacts in response to these complex challenges. The authors conceptualize DT as transformations of smart service systems (SSSs) due to the widespread use of smart technologies by individuals. The monograph further develops this literature toward a more sociological understanding of the practices within which individuals interact with smart technologies in their everyday lives. Based on these cornerstones, the authors provide specific suggestions for IS design of DT at a societal scale and contribute to research about DT, SSS, and IS design, respectively.