Step by step simulation procedure including key technical parameters and neutral layout to be implemented in any available flowsheet simulator, thermo package recommendation and design tips specific for each type of presented unit/process. Starting from Upstream processes like FPSO/GOSP, then passing to Midstream with NGL recovery and complete fractionation train, mercury removal, glycol & molecular sieve dehydration, amine unit, then arriving Downstream to Refinery where crude, vacuum & condensate distillation units are touch, various strippers like: NHT, distillate, VGO, reformate splitter and stripper are presented, FCC & hydrocracking separation sections, saturated gas plant, sour water stripping unit plus sulfur recovery & TGT and finally to Petrochemical sector where PP Splitter with heat pump, BT fractionation and aromatic separation are presented. Also four special chapters are part of the book, MDMT rigorous calculation including tensile stress of wall expose to fire with practical examples (one vessel and multiple equipment protected by the same depressurization valve), HIPPS implementation for FPSO and toluene separation (dynamic simulation layout with integrator settings and various scenarios), CPA validation against experimental data with extensive graphs showing equilibrium for various available experimental data and DWC Opex & Capex quick tips and simulation / optimization tricks. At the end of each chapter the reader shall find ''take away'' section with useful information to be discovered.