How is a loving, powerful, good, and cognizant God related to human lives that are beset with pain and suffering and plagued by diseases and natural catastrophes? What is the role and activity of God in history and nature? How does God help us in our struggles and our tragedies? God, Pandemics, and the Holocaust suggests answers to these questions and others through the prisms of the bubonic plague, the Spanish flu, COVID-19, and the attempted genocide of the Jewish people in the Holocaust. Religious insights from these time periods are noted and additional and alternative points of view are also considered. The existence of God is not examined; what is explored is the kind of God who God is: What conceptions of God are no longer satisfactory to human experience, and what understandings of God can make sense in a world that is both wonderful and woeful?