Devastated by the death of her husband and sons, Hannah Mercer sells the family farm and creates a store and living quarters in a delivery truck. As she travels several circuits selling her wares, Hannah becomes the heart of a network of interlinking lives: Nathan owns the motel where Hannah often parks her truck. Darla is a young and talented deaf artist, whose parents let her accompany Hannah on her rounds. Wanda, the sassy receptionist at a hardware distribution center, has larger ambitions. Naomi, wife of the pious Mennonite deacon, entertains fantasies of sexual freedom. Frank, a gentle farmer with a chronically-ill wife, harbors great affection for Hannah, but has troubling biases. LeRoy is a black farmer and talented singer, yet his family is subjected to racial terrorism. Velma owns a woodworking shop. Is she a good match for Vivian, Ronan County's elegant, lesbian librarian?

Larry... Maddie ... Tom... Molly. As time passes and Hannah's relationships deepen, her faith diminishes but her vision of humanity expands. Hannah Mercer is a clever problem-solver, a shrewd schemer, a spinner of tender lies, an advocate for justice, and a dream weaver.