Introduction to Biomedical Data Science aims to fill the data science knowledge gap experienced by many clinical, administrative and technical staff. The textbook begins with an overview of what biomedical data science is and then embarks on a tour of topics beginning with spreadsheet tips and tricks and ending with artificial intelligence. In between, important topics are covered such as biostatistics, data visualization, database systems, big data, programming languages, bioinformatics, and machine learning. The textbook is available as a paperback and ebook. Visit the companion website at https: //www.informaticseducation.org for more information. Key features: Real healthcare datasets are used for examples and exercises; Knowledge of a programming language or higher math is not required; Multiple free or open source software programs are presented; YouTube videos are embedded in most chapters; Extensive resources chapter for further reading and learning; PowerPoints and an Instructor Manua