Four travelers meet in Bolivia and set off into the heart of the Amazon rainforest, but what begins as a dream adventure quickly deteriorates into a dangerous nightmare, and after weeks of wandering in the dense undergrowth, the four backpackers split up into two groups.

But when a terrible rafting accident separates him from his partner, Yossi Ghinsberg is forced to survive for weeks alone against one of the wildest backdrops on the planet. Stranded without a knife, map, or survival training, he must improvise shelter and forage for wild fruit to survive. As his feet begin to rot during raging storms, as he loses all sense of direction, and as he begins to lose all hope, he wonders whether he will make it out of the jungle alive.