During the 19th century, Italian opera became truly transatlantic and its rapid expansion is one of the most exciting new areas of study in music and the performing arts. Beyond the Atlantic coasts, opera searched for new spaces to expand its reach. This Element discusses about the Italian opera in Andean countries like Chile, Peru, Ecuador and Bolivia during the 1840s and focuses on opera as a product that both challenged and was challenged in the Andes by other forms of performing arts, behaviours, technologies, material realities, and business models.