Since the dawn of time, the Izuna wolves have been entrusted as guardians against Japan's evil spirits without piercing the veil that keeps the spirit world of the Kami and the human world separate. One day, a dark force known as the Noggo appears, spreading infection among the spiritual plane, and the Izuna, sworn to protect this realm, attempt to fight it off. But when an Izuna cub is born in the shape of a young human girl, the divide between the spirit world and the waking world becomes threatened.