On a dig in a Spanish desert, archeologist, Jennifer Moore uncovers the skeleton of a young Neanderthal, a prehistoric branch of humans that mysteriously vanished. In its hand is a bone flute. But Neanderthals were not known to create music.

40,000 years earlier, Skeetu, one of the last remaining Neanderthals, finds a flute. This leads her to a small band of Homo sapiens-our ancestors. With her Woolly Rhino, Bulo, they travel together in search of more of their kind. Saber-toothed tigers, monstrous hyenas, cave bears, wolves, and winter storms challenge their survival.

Forward to present time: Jennifer is racing backwards through her dreams; seeing through the eyes of one ancestor to the next. Could it have something to do with the flute she stole from the dig site?

Neandergirl is in essence a time travel story, joining family across the span of 40,000 years, and plays with the challenges of companionship-not between two races, but two different species of human beings.