For reclusive germophobe, Frank Talbot, dealing with his crippling fear of contamination and germs has always been a challenge, but now he may have no choice. After a mysterious outbreak of a highly lethal virus ravages the globe and hundreds succumb to the contagious illness, the U.S government instigates a cordon sanitaire in major cities to contain it from spreading rapidly around the nation. At the onset of the epidemic, his ex-wife, Kate, an epidemiologist for the CDC, warns Frank and their daughter, Ella to prepare for the worst. The only hope of survival is retreating to their cottage on one of the isolated islands in the St. Lawrence River. Easy for Frank, he's already there but when his daughter suffers a major setback, Frank is forced out of his comfort zone. As riots ensue and electrical fences are breached, the H9N3 Agora Virus is unleashed and becomes unstoppable. Transportation systems cease, grocery stores are looted, hospitals become infectious morgues, and chaos erupts. Now his greatest fear is about to become his reality. Frank must embark on a dangerous journey into the heart of an infected country, to rescue his daughter before society collapses. Will ruthless men stop him, or his own fear?