Richard Shepherd was born in West London but grew up in Watford. At the local grammar school he was introduced to a medical textbook smuggled into the classroom by a friend which opened his eyes to the world of crime and murder, setting him on a lifelong quest to understand death in its many forms. He trained as a doctor at St George's Hospital medical school at Hyde Park Corner, qualifying in 1977 and then completed his postgraduate training as a forensic pathologist in 1987. He immediately joined what was then the elite forensic department at Guy's Hospital.

He has been involved nationally and internationally in the forensic investigation of thousands of deaths from unnatural causes, from headline-making murders to mass natural disasters, and many sudden and unexplained deaths that his investigations showed were from natural causes or due to accidents. His skills and expertise still remain in demand around the world.