While one might say that prehistory of the Adriatic was always in transition, the rhythm of change was not always the same. On several occasions, a series of changes over a relatively short time period resulted in dramatic transformations. Three crucial episodes of change marked the later Adriatic prehistory. The first one, which took place around year 6000 BC, was a transformation of subsistence strategy, transition from hunting and gathering to farming. The second one was a social transformation that played out in the third millennium BC, when for the first time the power of individuals was clearly expressed by material culture. The third episode, inclusion into the classic Mediterranean civilization, coincided with the end of prehistory in the Adriatic region. During all of those episodes, travel and connectivity with distant lands played an exceptionally important role, and certain places gained particular importance due to their unique geographic location. Palagruza is among the most prominent such places, its importance being out of all proportion to its physical size. Adriatic prehistory cannot be told without mentioning Palagruza, and prehistory of Palagruza cannot be understood without knowing Adriatic prehistory. Due to its strategic position in the very center of the Adriatic Sea, due to the mystery born of distance and isolation, due to its wild and spectacular landscape, Palagruza indeed is a special place. A reflection of its specialty is an unexpected abundance of high-grade archaeological evidence, dating precisely from the three aforementioned periods marked by radical change.