Venice, 1612. Two very different women, a notorious courtesan and a Talmudic scholar, are brought together by an artist when they pose for a "Gallery of Beauties," forming a relationship neither of them anticipated.

Conflicted about her past, Belladonna finds herself drawn to Diana, the rabbi's widowed daughter, and has ambitions for her future, but only if Diana will discard her origins and her traditions. While Diana is torn by indecision, Belladonna feels threatened, as one by one, the subjects of the portraits are poisoned. The two women must rely on their wits and each other to avoid becoming the next victims, as they confront the powerful men who seek to control them and Venice.