The Isis Thesis is a transdisciplinary study of eight major ancient Egyptian texts, revealing that over 870 decoded signs, including art and architecture, communicate modern scientific knowledge about microbiology and human potential for genetic immortality. Put simply, the Egyptian afterlife is the quantum domain, and their deities are signs for microbial genes and proteins, describing a biophysical process of horizontal gene transfer (DNA exchange between species) for radical human evolution.The initial methodology included multiple reviews of the least corrupted Pyramid and Coffin Texts to categorize 108 key themes that were synthesized into 30 major idea strands, defining textual events and activities of major deities. From this analysis, a hypothetical biological model of primary signs emerged for further testing in six additional texts: Amduat, Book of Gates, Book of Two Ways, Edifice of Taharqa, Papyrus of Ani including the Theban Recension. Abductive reasoning allowed modifications to the working model with verification of Egyptian principles supported by modern scientific research. A logical, holistic matrix emerged, explaining horizontal gene transfer as an option for afterlife transformation.On the quantum level of DNA transcription, the texts depict and describe proteins binding, folding and tunneling, using modern terms and images to explain black hole/white hole formation/evaporation processes. Thus, they translate a DNA wormhole into a quantum mechanical Einstein-Rosen bridge back to the Early Universe. In this biophysical evolutionary process, the activities of Egyptian deities are signs explaining the ancient glycolysis gene expression network in our cells and the lifestyles of a complex bacterial virus that uses this ancient developmental pathway.Surprisingly, other historical religious deities mirror the activities of Egyptian deities, so religion has also preserved an evolutionary science for survival of human DNA in a quantum environment. The study spanning 2000 years of Ancient Egyptian texts reveals a microbiological basis for pharaonic psychology, literature, architecture and art. In this consistent model, the value or meaning of each sign emerged, not by choice, but rather from an analysis of each sign's interaction within a matrix of 870 interlinked thematic signs. The texts support an option for postmortem evolution that is mediated by an ancient virus called bacteriophage Lambda.The Isis Thesis presents scientific evidence t