A mysterious pandemic causes a quarter of the world's population to permanently lose the ability to sleep--without any apparent health implications. The outbreak creates a new class of people who are both feared and ostracized, and most of whom optimize their extra hours to earn more money.

Jamie Vega, a New York journalist at C+P Media, is one of the Sleepless. When his irascible boss dies in an apparent suicidal overdose, Jamie doesn't buy this too-convenient explanation--especially given its suspicious timing in the middle of a corporate takeover--and begins to investigate.

Things go awry quickly when Jamie discovers that he was the last person who saw Simon alive. Retracing his steps, he realizes he doesn't remember that night. Not only do the police suspect him, Jamie can't account for the lost time, and the memory loss may have something to do with the fact that he did not come by hyperinsomnia naturally: through a risky and illegal process, Jamie had biohacked himself to become Sleepless.

As Jamie delves deeper into Simon's final days, he is forced to confront past traumas, and the consequences of his decision to biohack himself. Along the way he uncovers a terrifying truth about what it means to be Sleepless that will imperil him--and all of humanity.