Los Angeles, 1962. Dr. Wiley McCoy has a successful medical practice, movie-star good looks, and a substance abuse problem. When a young woman dies on his operating table, his life and career are destroyed. Romulo DaVinci is a conniving Voodoo shaman with supernatural powers to resurrect the dead. The disgraced doctor and the medical adventurer are thrown together on a gonzo journey through the seminal events of the 1960's including the JFK assassination, the Apollo moon landing, and the Manson killings. Along the way, they commandeer a U.S. nuclear submarine and encounter real-life characters from bonkers plutocrat Howard Hughes to ruthless Haitian leader Papa Doc Duvalier.

The Thresher Ghost is a carnival ride through a tumultuous decade--its music, its conspiracies and its scandals--as McCoy and DaVinci cross oceans and medical boundaries in a duel between science and magic.