Murphy, the phat cat, is unique because of his thirty-five-pound body size and his warm and sensitive nature. There are two things that this cat can't refuse: lending a helping paw to his fellow-furry neighbors and his cravings for tuna fish.

The gossip queen of cats, Maisie Mums, comes to Murphy to fill him in with the problem on how the neighborhood cats have fallen victim to annoying pestering from a gang of bullying burrowing owls. The gang is led by an old, wise owl named, Don Owl Leon, and they have just recently moved to his neighborhood of Majestic Groves, causing chaos.

With the advice from his chameleon adviser, Gaidan, the protection from his bodyguard bulldog, Ruthless Riley, and the assistance of his friends, the two Siberian husky sisters, he decides to try and come up with a solution. However, the plan changes when the owls kidnap, Peanut, his sister-cat. Murphy must come up with a new answer, and his true feline character is put to the test.

After coming to the realization that the owls are acting malicious due to their subconscious fear of loss of habitat, Murphy and some friends decide to help the owls by putting together a project to preserve the owls' existence. They can't do it alone; the implementation of the project depends on Murphy's human owner, Teresa. They mysteriously give her the plan for a project that can change the fate of the owls, and little does she know that the animals there had something to do with its creation.

Will the animals realize they're more alike than they are different? Why can't all types of species live in harmony among one another? Isn't there's enough room for all of them, even if it is together in small suburbia in Florida.