Charlotte is the daughter of James Worthington, a wealthy tobacco plantation owner and enslaver. Simone, the daughter of a slave, was taken from her mother's arms and sold to James.

When Simone arrives at Huntington Manor Plantation at seven years old, she and Charlotte have an immediate bond.

But as the girls mature, there is no denying their different positions on the plantation-Charlotte is privileged, and Simone is an enslaved servant.

Then, fourteen-year-old Tilby Smith, another slave purchased by Charlotte's father, arrives on the plantation, and shortly afterward, he and Simone become confidants, keeping secrets from the other slaves-and even Charlotte. But, Tilby and Simone soon find themselves in a dire situation...

Charlotte wants to help her friend and soon discovers that her sheltered and obedient life becomes one of rebellion, conviction, and undying sacrifices.

Pompey Hollow Road explores friendship at its fondest in the 1800s at the height of slavery and abolition-and how far one will go to protect another from the injustices of society.